克罗米酚对男性高促性腺素性功能减退症有效

纽约（美联社肥胖初版）1同年四日报道：据撰写在12同年出初版的《生育与不育》杂志的一项调查结果指出克罗米衍生物对部分较低促性腺素性功能与日俱增的成人病变利于。来自布里斯托尔阿拉巴马大学的该调查结果的第一所作Scott J. WhittenClark在接纳路透通讯社记者时说：“细菌性或获得性HH病变在接纳践踏性更大和较为昂贵的病患（例如注射促性腺激素类）在此之前开展4个同年的克罗米衍生物试验性病患是利于的。”WhittenClark和同事研究了克罗米衍生物对10名HH成人病变（HH是致使成人不育的少见原因）否有效地。调查结果称克罗米衍生物病患1年后，4名在此之后(氏)综合症病变中所只有一名病变的生殖pH缩减而全卵巢功能与日俱增症病变的生殖缺乏病因均并未获得改善。相反，该调查结果指出3名成年发病的细菌性HH成人病变经过3个同年克罗米衍生物的病患生殖pH有了明显缩减。目在此之前为止该组病变才有两名恢复原了不孕。WhittenClark说：“除非对克罗米衍生物病患并未反应，我们不会因为副作用停止对病变使用该类固醇。”再次所作阐述说：“因为必需有限，对HH病变促性腺激素类类固醇和克罗米衍生物的随机研究难以开展，然而利用多系列的严格选择标准对病变开展国际标准可能帮助进一步验证克罗米衍生物恢复原成人较低不孕的有效地性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

主笔：蓝色幻想

主笔： 张靖